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Adiponectin is an adipocytokine that has recently attracted attention as a new insulin-sensitizing adipocytokine. The present study evaluated the relationship between dietary factors, including those of fat, carbohydrate and vitamin E, and plasma adiponectin concentrations in Japanese male subjects. In this cross-sectional study, a diet survey was conducted for 31 men who did not consume foods containing trans fats or excessive amounts of saturated fats and cholesterol, and another for 60 men who reported consuming such foods. Mean (SD) age was 53.8 (11.0) years. Body weight was significantly correlated with plasma adiponectin concentration, but not with serum total cholesterol, high-density lipoprotein (HDL)-cholesterol or other blood lipids. Multiple linear regression analysis showed that average intake of dietary fat and/or serum adiponectin was associated with the body mass index (BMI), but not with serum lipids. In the patients with an excess intake of dietary cholesterol, average dietary cholesterol intake was associated with the BMI. In the patients without a dietary cholesterol excess, average dietary fat intake was significantly associated with the serum adiponectin concentration. In the patients with a normal or high BMI, but who did not regularly consume any foods containing trans fats or saturated fats, those who consumed a greater amount of dietary vitamin E had higher adiponectin concentrations. However, these relationships were not observed in the patients with an excess intake of dietary cholesterol, in patients with a low BMI, or in patients with both high BMI and an excess intake of dietary cholesterol. These findings suggest that the potential use of dietary factors as a tool for improving metabolism and/or health conditions, or for the prevention and/or treatment of diseases, should be considered carefully, particularly in male subjects with an excess intake of dietary cholesterol, or in those with a low BMI and an excess intake of dietary fat.Conceptual systems level model of Alzheimer’s disease with synuclein self-associated protein.
Alzheimer’s disease (AD) is the most common form of dementia
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